Example of Clozapine Titration Schedule

Week 1 AM Dose (mg) PM Dose (mg) Total Daily Dose (mg) Day 1 12.5 12.5 optional 12.5-25 Day 2 25 ---- 25 Day 3 25 25 50 Day 4 25 50 75 Day 5 50 50 100 Day 6 50 75 125 Day 7 50 100 150   Week 2 AM Dose (mg) PM Dose (mg) Total Daily Dose (mg) Day 8 75 100 175 Day 9 100 100 200 Day 10 100 125 225 Day 11 100 150 250 Day 12 125 150 275 Day 13 150 150 300 Day 14 150 150 300

Doses can be increased with daily dosage increments of 25 to 50 mg/day, if well tolerated, to achieve a target dose of 300 to 450 mg/day by the end of 2 weeks. After Week 2, subsequent dosage increments should be made no more than once or twice weekly, in increments not to exceed 100 mg. Cautious titration and a divided dosage schedule are necessary to minimize the risks of hypotension, seizure, and sedation. Source: Teva Clozapine Package Insert.